Safety and Pharmacokinetics of Single-Dose Novel Oral Androgen 11 <i>β</i> -Methyl-19-Nortestosterone-17 <i>β</i> -Dodecylcarbonate in Men

Abstract

A single, oral dose of 11β-MNTDC up to 800 mg administered with food is safe and well tolerated in healthy men. The active drug 11β-MNT has androgenic and progestational activity, rapidly suppresses serum testosterone, and is a promising candidate for an effective once-daily oral male hormonal contraceptive.