Green and Efficient Synthesis of <i>N</i>-Sulfenyl Sulfoximines in Water

Abstract

A new and metal-free cross-coupling reaction between sulfoximines and N-(phenylthio)-succinimides was developed in water, afforded an efficient route for the synthesis of N-sulfenyl sulfoximines. This transformation provides N-sulfenyl sulfoximines with good functional group tolerance and moderate to excellent yields. Moreover, this protocol can be easily scaled up to the gram level with excellent yield.