An Efficient Metal‐Free Mono N‐Alkylation of Anilines via Reductive Amination Using Hydrosilanes

Abstract

2‐Aminoquinazolin‐4‐one based efficient organocatalytic eco‐friendly reductive amination approach was developed for the mono N‐alkylation of anilines using hydrosilane as a reducing agent. This practically easy and sustainable approach works under neat reaction conditions and utilizes non‐toxic environmentally benign acetic acid as a dehydrating agent. The developed protocol have several advantages, such as broad substrate scope, wide functional group tolerance, short reaction time, and absence of metal catalyst in the reaction.