An indole diterpenoid isolated from the fungus <i>Drechmeria</i> sp. and its antimicrobial activity

Abstract

One new indole diterpenoid, drechmerin I (<b>1</b>), was isolated from the fermentation broth of <i>Drechmeria</i> sp. isolated from the root of <i>Panax notoginseng</i>. Its structure was elucidated based on 1 D and 2 D nuclear magnetic resonance (NMR), high resolution electrospray ionization mass spectrum (HRESIMS), and electronic circular dichroism (ECD) spectroscopic analyses as well as TD DFT calculations of ECD spectra. Drechmerin I (<b>1</b>) was assayed for its antimicrobial activity against <i>Candida albicans</i>, <i>Staphylococcus aureus</i>, <i>Bacillus cereus</i>, <i>B. subtillis</i>, <i>Pseudomonas aeruginosa</i>, and <i>Klebsiella pneumonia</i>, respectively. Drechmerin I (<b>1</b>) showed antimicrobial activities against <i>B. subtillis</i> with an MIC value of 200 μg/mL. The interaction of <i>S. aureus</i> peptide deformylase with drechmerin I (<b>1</b>) was investigated by molecular docking.