Proceedings of the National Academy of Sciences · 2018 · 22 citations · 64 references
Life SciencesNeurobiologyNeuroscienceMolecular NeuroscienceNeuropharmacologyNeurophysiologyAddictionAddiction NeurobiologyDrug DependenceNeurotransmissionReward PathwaysSynaptic TransmissionBrain Reward CircuitryChannelsDopaminergic NeurophysiologyDopaminergic PathwaysDopaminergic Reward CircuitryLocomotor SensitizationMesolimbic Reward PathwayReward Pathway Dysregulation
Significance Activation of G protein-gated inwardly rectifying potassium (GIRK) channels inhibits neuronal activity in the brain, but details are lacking on how this important pathway influences neural circuits in the reward pathway. Here, we provide an example of where control of trafficking of GIRK channels by a cytoplasmic protein, sorting nexin 27, determines the sensitivity of mice to cocaine in a model of addiction known as locomotor sensitization. These results implicate GIRK channels as a therapeutic target for treating addiction, as well as other psychiatric disorders involving dopamine dysregulation.
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The βγ subunits of GTP-binding proteins activate the muscarinic K+ channel in heart
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