Design, synthesis, antiproliferative activity and docking studies of quinazoline derivatives bearing oxazole or imidazole as potential EGFR inhibitors

Abstract

Six series of quinazoline derivatives bearing oxazole or imidazole (<bold>8a–f</bold>, <bold>9a–f</bold>, <bold>10a–d</bold>, <bold>11a–f</bold>, <bold>12a–d</bold> and <bold>13a–i</bold>) were designed, synthesized and their IC₅₀ values evaluated against three cancer cell lines (A549, MCF-7 and PC-3).