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Methylation of Amines and Ketones with Methanol Catalyzed by an Iridium Complex Bearing a 2-Hydroxypyridylmethylene Fragment
92
Citations
50
References
2018
Year
EngineeringMethanolOrganic ChemistryChemistry2-Hydroxypyridylmethylene FragmentChemical EngineeringComplexes 1–3Iridium Complex BearingOrganometallic CatalysisHomogeneous Catalysis−Oh DeprotonationCross-coupling ReactionCatalysisInorganic SynthesisCoordination ComplexMolecular ComplexMethanol CatalyzedMolecular CatalysisHigh Activity
Reaction of complex [Cp*Ir(HOC5H3CH2C5H3OH)Cl][Cl] (1) with AgOTf generated the product [Cp*Ir(HOC5H3CH2C5H3OH)(H2O)][OTf]2 (2), which was further transformed to the complex [Cp*Ir(OC5H3CH2C5H3O)(H2O)] (3) in the presence of t-BuONa via −OH deprotonation. Complexes 1–3 exhibited high activity for the methylation of amines and ketones. These C–C and C–N coupling reactions proceeded in air with 1 mol % catalyst loading in the presence of K2CO3.
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