Electronic biosensing with flexible organic transistor devices

Abstract

In this short review, we summarize the design and implementation of organic semiconducting materialsbased field-effect transistors (OFETs) and the fabrication and use of reduced graphene-oxide field-effect transistors (rGO-FETs) as flexible transducers for electronic biosensing. We demonstrate that these platforms allow for the quantitative, in situ, and in real time monitoring of bio-affinity reactions between analytes from solution to the surface-immobilized receptors. The examples given include the binding of anti-bovine serum albumin (BSA) antibodies to their antigen, BSA, covalently attached to the channel of an OFET, or the reverse mode of operation, i.e., the binding of BSA from solution to the antibodies immobilized on a rGO transistor. Finally, we will discuss a few results obtained with odorant binding proteins used as receptors on a rGO-FET transducer for the realization of a biomimetic smell sensor.