Highly Substituted Benzophenone Aldehydes and Eremophilane Derivatives from the Deep-Sea Derived Fungus Phomopsis lithocarpus FS508

Abstract

Five new benzophenone derivatives named tenellones D⁻H (<b>1</b>⁻<b>5</b>), sharing a rare naturally occurring aldehyde functionality in this family, and a new eremophilane derivative named lithocarin A (<b>7</b>), together with two known compounds (<b>6</b> and <b>8</b>), were isolated from the deep marine sediment-derived fungus <i>Phomopsis lithocarpus</i> FS508. All of the structures for these new compounds were fully characterized and established on the basis of extensive spectroscopic interpretation and X-ray crystallographic analysis. Compound <b>5</b> exhibited cytotoxic activity against HepG-2 and A549 cell lines with IC₅₀ values of 16.0 and 17.6 μM, respectively.