Tricyclic Antidepressants Modulate Stressed Mitochondria in Glioblastoma Multiforme Cells

Abstract

In the light of reported studies, the mitochondrial disturbance observed in glioma cells is a dynamic process that can be reversed or silenced. Moreover, imipramine and amitriptyline are attractive cellular metabolic modulators and can potentially be used to restoring a proper function of mitochondria in GBM cells.