Inverse‐Electron‐Demand [4+2]‐Cycloaddition of 1,3,5‐triazinanes: Facile Approaches to Tetrahydroquinazolines

Abstract

Abstract An unprecedented inverse‐electron‐demand [4+2] cycloaddition reaction of in situ generated aza‐ o ‐quinone methides with 1,3,5‐triazinanes has been developed under mild conditions, providing an efficient and mild approach to synthesize tetrahydroquinazolines in high yields (up to 99%) with excellent functional group tolerance. This protocol represents the first example of inverse‐electron‐demand [4+2] cycloaddition reaction of 1,3,5‐triazinanes. magnified image