Pharmacological characterization of the orexin/hypocretin receptor agonist Nag 26

Narcolepsy in orexin Knockout Mice

Richard M. Chemelli, Jon T. Willie, Christopher M. Sinton et al. · Cell · 1999 · 3.1K citations · Full text

Life Sciences, Neurobiology, Neuroscience +12

The Sleep Disorder Canine Narcolepsy Is Caused by a Mutation in the Hypocretin (Orexin) Receptor 2 Gene

Ling Lin, Juliette Faraco, Robin Li et al. · Cell · 1999 · 2.6K citations · Full text

Medicine, Neurology, Neuroscience +13

Genetic Ablation of Orexin Neurons in Mice Results in Narcolepsy, Hypophagia, and Obesity

Junko Hara, Carsten T. Beuckmann, Tadahiro Nambu et al. · Neuron · 2001 · 1.4K citations · Full text

Life Sciences, Neurobiology, Neuroscience +13

Distinct Narcolepsy Syndromes in Orexin Receptor-2 and Orexin Null Mice

Jon T. Willie, Richard M. Chemelli, Christopher M. Sinton et al. · Neuron · 2003 · 647 citations · Full text

Life Sciences, Neurobiology, Neuroscience +12

Orexin peptides prevent cataplexy and improve wakefulness in an orexin neuron-ablated model of narcolepsy in mice

Michihiro Mieda, Jon T. Willie, Junko Hara et al. · Proceedings of the National Academy of Sciences · 2004 · 342 citations · Full text

Medicine, Neuroscience, Pharmacology +17