PLACENTAL MONOCYTE INFILTRATES IN RESPONSE TO PLASMODIUM FALCIPARUM MALARIA INFECTION AND THEIR ASSOCIATION WITH ADVERSE PREGNANCY OUTCOMES

Maternal anemia and low birth weight (LBW) may complicate malaria in pregnancy, and placental monocyte infiltrates have been associated with LBW, and anecdotally with anemia. We examined placental pathology from 357 Malawian women. Intervillous monocyte infiltrates were frequent in placental malaria and were not seen in uninfected placentas. Histology was grouped according to a 5-point scale. Dense monocyte infiltrates and presence of intramonocytic malaria pigment were associated with anemia and LBW. Of factors associated with LBW and/or anemia in univariate analysis, gravidity ( P = 0.002), number of antenatal clinic (ANC) visits ( P < 0.001), malaria pigment in fibrin ( P = 0.03), and monocyte malaria pigment ( P = 0.0001) remained associated with lower birth weight by multivariate analysis. Associated with maternal anemia were HIV infection ( P < 0.0001), intervillous monocyte numbers ( P < 0.0001), number of ANC visits ( P = 0.002), and recent febrile symptoms ( P = 0.0001). Pigment-containing placental monocytes are associated with anemia and LBW due to malaria, and may have a causative role in their development.