The Collaborative Ocular Tuberculosis Study (COTS)-1: A Multinational Description of the Spectrum of Choroidal Involvement in 245 Patients with Tubercular Uveitis

Abstract

<i>Purpose</i>: To contribute a global description of the spectrum of choroidal involvement in tubercular uveitis (TBU).<i>Methods</i>: Retrospective cohort study of TBU patients with choroidal involvement from 25 centers between January 2004 and December 2014. Medical records of patients with a minimum follow-up of 1 year were reviewed.<i>Results</i>: 245 patients were included. The phenotypic variations included serpiginous-like choroiditis (SLC) (46%), tuberculoma (13.5%), multifocal choroiditis (MFC) (9.4%), ampiginous choroiditis (9%), among others. 219 patients were treated with anti-tubercular therapy (ATT) (<i>n</i> = 219/245, 89.38%), 229 patients with steroids (<i>n</i> = 229/245, 93.47%) and 28 patients with immunosuppressive agents (<i>n</i> = 28/245, 11.42%). Treatment failure was noted in 38 patients (<i>n</i> = 38/245, 15.5%). Patients with SLC and ampiginous choroiditis appeared to have superior outcomes on survival analysis (<i>p</i> = 0.06).<i>Conclusion</i>: This study provides a comprehensive description of choroidal involvement in TBU. Patients with SLC and ampiginous choroiditis may have better clinical outcomes.