Probing Dynamic Library of Metal-Oxo Building Blocks with γ-Cyclodextrin

Abstract

Formation of one of the most representative polyoxometalate (POM) archetypes, namely the Lindqvist anion M₆O₁₉^2- with M = Mo^VI or W^VI, was considered as elusive in aqueous solution. Herein, we report on the host-guest stabilization of the M₆O₁₉^2- species with M = Mo or W from aqueous solution using γ-cyclodextrin as trapping agent. The adduct {M₆O₁₉@γ-CD}^2- reveals remarkable hydrolytic stability that offers new opportunities for exploring potentialities of molybdates or tungstates in the field of biology and medicine, when combined to CDs as efficient drug carrier/delivery agents.