Reversing Multidrug Resistance in Chemo-resistant Human Lung Adenocarcinoma (A549/DOX) Cells by Algerian Propolis Through Direct Inhibiting the P-gp Efflux-pump, G0/G1 Cell Cycle Arrest and Apoptosis Induction - Concepedia

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Reversing Multidrug Resistance in Chemo-resistant Human Lung Adenocarcinoma (A549/DOX) Cells by Algerian Propolis Through Direct Inhibiting the P-gp Efflux-pump, G0/G1 Cell Cycle Arrest and Apoptosis Induction

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2018

Year

Wided Kebsa, Mesbah Lahouel, Hassiba Rouibah, Malek Zihlif, Mamoun Ahram, Bashaer Abu‐Irmaileh, Ebtihal Mustafa, Hamzeh J. Al‐Ameer, Mohammad Al Shhab

Anti-Cancer Agents in Medicinal Chemistry

Abstract

Taken together, Algerian propolis reverses multidrug resistance in resistant human lung adenocarcinoma cells through direct inhibiting the transport function of pgp-pump resulting in enhancing intracellular DOX-accumulation, G0/G1 cell cycle arrest and apoptosis induction. Thus, propolis could be developed as a chemotherapeutic agent for reversing multidrug resistance.