Fine-scale differentiation between <i>Bacillus anthracis</i> and <i>Bacillus cereus</i> group signatures in metagenome shotgun data

Abstract

This work shows how extensive libraries of complete genomes can be used to create organism-specific signatures to help interpret metagenomes. We contrast "specialist" approaches to metagenome analysis such as this work to "generalist" software that seeks to classify all organisms present in the sample and note the more general utility of a k-mer filter approach when taxonomic boundaries lack clarity or high levels of precision are required.