Concepedia

Inactivation of PBX3 and HOXA9 by down-regulating H3K79 methylation represses NPM1-mutated leukemic cell survival

Wu Zhang, Chen Zhao, Junmei Zhao, Yongmei Zhu, Xiangqin Weng, Qiusheng Chen, Huiping Sun, Jian‐Qing Mi, Junmin Li, Jiang Zhu,

Theranostics · 2018 · 44 citations · 40 references

DOIFull text

Open access

Concepts

Abstract

Our data indicate that NPMc+ leukemic cell survival requires upregulation of PBX3 and HOXA9, and this action can be largely attenuated by a DOT1L inhibitor.

References

40

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data

Ethan Cerami, Jianjiong Gao, Uğur Doğrusöz et al. · Cancer Discovery · 2012 · 18.4K citations · Full text

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Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

Jianjiong Gao, Bülent Arman Aksoy, Uğur Doğrusöz et al. · Science Signaling · 2013 · 15.9K citations · Full text

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Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia

New England Journal of Medicine · 2013 · 5.2K citations · Full text

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Cytoplasmic Nucleophosmin in Acute Myelogenous Leukemia with a Normal Karyotype

Brunangelo Falini, Cristina Mecucci, Enrico Tiacci et al. · New England Journal of Medicine · 2005 · 1.9K citations · Full text

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The Origin and Evolution of Mutations in Acute Myeloid Leukemia

John S. Welch, Timothy J. Ley, Daniel C. Link et al. · Cell · 2012 · 1.6K citations · Full text

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