Successful treatment of C. auris shunt infection with intraventricular caspofungin

Abstract

<i>C. auris</i> is an emerging fungal pathogen with high prevalence of resistance to current antifungal agents. Central nervous system infection with <i>C. auris</i> has been infrequently described. We describe here an adult with nosocomial CSF shunt infection due to multi drug resistant <i>C. auris</i>. Systemic therapy with echinocandin and flucytosine failed. Fortunately, administration of daily intraventricular caspofungin 10 mg for 10 days in conjunction with systemic voriconazole resulted in both clinical and microbiological cure.