BioMed Research International · 2018 · 57 citations · 35 references
MedicineOral SurgerySurgeryOncologic SurgeryOral Cancer SurgeryOral OncologyLaser SurgeryOral Cavity CancerBisphosphonate Therapy ManagementCohort Study InvestigationConservative Surgical TreatmentJaw Bone LesionsLongitudinal Cohort AnalysisLongitudinal Cohort StudiesPlatelet-rich Plasma InjectionTreatment With Bisphosphonates
INTRODUCTION: The management of bisphosphonate-related osteonecrosis of the jaw (BRONJ), with no evidence-based guidelines, remains controversial. We aimed to evaluate the efficiency of a conservative surgical treatment combining Er,Cr:YSGG laser and platelet-rich plasma (PRP) for the treatment of BRONJ in cancer patients. METHODS: We performed a longitudinal cohort study. Inclusion criteria were (1) age ≥ 18 years; (2) cancer diagnosis; (3) treatment with NBP because of the underlying cancer. RESULTS: We consecutively recruited ten patients diagnosed with BRONJ in stage I or II. These patients underwent a surgical laser-assisted therapy together with autologous PRP. At the latest follow-up at 12 months, clinical improvement was observed in eight patients. Registration Number is IRCT20180329039159N1. CONCLUSION: We could successfully manage the BRONJ utilizing this combined protocol to heal the 30% of surgically treated sites and to improve the 50% of patients' lesions clinically. Our findings suggest that a surgical approach combined with Er,Cr:YSGG laser and PRP benefit cancer patients with general health issues.
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