Concepedia

Activating Autophagy Enhanced the Antitumor Effect of Antibody Drug Conjugates Rituximab-Monomethyl Auristatin E

Yichen Wang, Xuyao Zhang, Jiajun Fan, Wei Chen, Jingyun Luan, Yanyang Nan, Shaofei Wang, Qicheng Chen, Yujie Zhang, Youling Wu,

Frontiers in Immunology · 2018 · 24 citations · 33 references

DOIFull text

Open access

Abstract

Our data elucidated the critical relationship between autophagy and apoptosis in Rituximab-MMAE-based therapy and highlighted the potential approach for NHL therapy by combined administration of the ADC and autophagy activator.

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