The EU approved antimalarial pyronaridine shows antitubercular activity and synergy with rifampicin, targeting RNA polymerase

Global tuberculosis report (2014)

L.A. Gabbasova, E.R. Experts Who · 2014 · 13.2K citations

Public Health, Infectious Diseases, Microbiology +12

The Connectivity Map: Using Gene-Expression Signatures to Connect Small Molecules, Genes, and Disease

Justin Lamb, Emily Crawford, D. D. Peck et al. · Science · 2006 · 5.5K citations

Life Sciences, Bioinformatics, Molecular Biology +16

Resazurin Microtiter Assay Plate: Simple and Inexpensive Method for Detection of Drug Resistance in <i>Mycobacterium tuberculosis</i>

Juan-Carlos Palomino, Anandi Martin, Mirtha Camacho et al. · Antimicrobial Agents and Chemotherapy · 2002 · 1.2K citations · Full text

Veterinary Medicine, Infectious Diseases, Pharmacology +15

Nalidixic acid resistance: A second genetic character involved in DNA gyrase activity

Martin Gellert, Kiyoshi Mizuuchi, M H O'Dea et al. · Proceedings of the National Academy of Sciences · 1977 · 829 citations · Full text

Life Sciences, Genetics, Microbiology +15

Mechanism of action of nalidixic acid: Purification of <i>Escherichia coli nalA</i> gene product and its relationship to DNA gyrase and a novel nicking-closing enzyme

Akio Sugino, Craig L. Peebles, Kenneth N. Kreuzer et al. · Proceedings of the National Academy of Sciences · 1977 · 782 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +15