Intraosseous pressure during loading and with vascular occlusion in an animal model

Abstract

This is the first study to report changes in IOP <i>in vivo</i> during loading and with combinations of vascular occlusion and loading. Intraosseous pressure is not a constant. It is reduced during proximal arterial occlusion and increased with proximal venous occlusion. Whatever the perfusion state, <i>in vivo</i> load is transferred partly by hydraulic pressure. We propose that joints act as hydraulic pressure barriers. An understanding of subchondral physiology may be important in understanding osteoarthritis and other bone diseases.<b>Cite this article</b>: M. Beverly, S. Mellon, J. A. Kennedy, D. W. Murray. Intraosseous pressure during loading and with vascular occlusion in an animal model. <i>Bone Joint Res</i> 2018;7:511-516. DOI: 10.1302/2046-3758.78.BJR-2017-0343.R2.