Small‐ and large‐sized iron(II, III) oxide nanoparticles for surface‐assisted laser desorption/ionization mass spectrometry of small biomolecules

Abstract

We have shown that transition-metal oxides such as Fe₃ O₄ nanoparticles are suitable and efficient surfaces for SALDI-TOF-MS analysis of small biomolecules. We observed improvement in signal-to-noise ratios and detection sensitivity for the analyzed samples from SALDI surfaces using small-sized (possessing larger surface area) than large-sized Fe₃ O₄ nanoparticles.