Organic Letters · 2018 · 22 citations · 58 references
Natural SciencesChemistryCatalysisOrganic ChemistryCatalyst DesignHeterocycle SynthesisHeterocyclic ChemistryHeterocyclic CompoundsHeterogeneous CatalysisOrganic SynthesisAsymmetric Heterocycle SynthesisHeterocyclic CatalysisHeterocyclic CatalystsHeterocyclic MaterialsHeterocyclic ReactivityMild Reaction ConditionsTransition-metal-catalyzed Heterocycle Synthesis
A DBU-catalyzed desymmetrization strategy between cyclohexadienones and isocyanates was discovered, affording a series of vicinal diamine-containing heterocycle derivatives in moderate to good yields and excellent diastereoselectivity under mild conditions. Furthermore, this reaction could be performed on a 10 g scale using 1.0 mol % of catalyst loading.
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