Dexmedetomidine Protects Against Chemical Hypoxia-Induced Neurotoxicity in Differentiated PC12 Cells Via Inhibition of NADPH Oxidase 2-Mediated Oxidative Stress

NADPH oxidase is the primary source of superoxide induced by NMDA receptor activation

Angela Brennan, Sang Won Suh, Seok Joon Won et al. · Nature Neuroscience · 2009 · 536 citations · Full text

Life Sciences, Neurobiology, Neuroscience +16

Pharmacokinetics of dexmedetomidine infusions for sedation of postoperative patients requiring intensive care †

R.M. Venn, Michael D. Karol, RM Grounds · British Journal of Anaesthesia · 2002 · 240 citations

Medicine, Anesthesiology, Pharmacokinetics +14

Neuroprotective Effects of Dexmedetomidine against Glutamate Agonist-induced Neuronal Cell Death Are Related to Increased Astrocyte Brain-derived Neurotrophic Factor Expression

Vincent Degos, Tifenn Le Charpentier, Vibol Chhor et al. · Anesthesiology · 2013 · 150 citations · Full text

Life Sciences, Neuroscience, Pharmacology +14

NADPH oxidases as therapeutic targets in ischemic stroke

Timo Kahles, Ralf P. Brandes · Cellular and Molecular Life Sciences · 2012 · 129 citations · Full text

Life Sciences, Biochemistry, Neuroscience +14

The neuroprotective action of dexmedetomidine on apoptosis, calcium entry and oxidative stress in cerebral ischemia-induced rats: Contribution of TRPM2 and TRPV1 channels

Hatice Akpınar, Mustafa Nazıroğlu, İshak Suat Övey et al. · Scientific Reports · 2016 · 106 citations · Full text

Medicine, Neuroscience, Pharmacology +17