ACS Catalysis · 2018 · 32 citations · 29 references
EngineeringBiotechnologyChemistryBiocatalysisBioorganic ChemistryCatalysisBiocatalyst DiscoveryBiocatalyst EngineeringCatalytic MechanismsIndustrial BiocatalysisIndustrial CatalysisWhole-cell BiocatalysisAromatization CatalysisBiocatalytic SynthesisMild Reaction ConditionsMonoamine Oxidase InhibitionMonoamine Oxidase InvolvementPyridine ChemistryPyridine SynthesisWhole-cell Biocatalytic Cascades
A sustainable MAO-N biocatalyzed process for the synthesis of pyridines from aliphatic tetrahydropyridines (THP) has been developed. Pyridine compounds were synthesized under mild reaction conditions and with high conversion, exploiting MAO-N whole cells as aromatizing biocatalysts. The kinetic profile of the whole cell biocatalytic transformation was finally investigated via in situ 19F NMR.
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