Detection and characterization of a clinical <em>Escherichia coli</em> ST3204 strain coproducing NDM-16 and MCR-1

Abstract

To the best of our knowledge, this is the first report to isolate an <i>E. coli</i> strain that coproduces NDM-16 and MCR-1. In addition, we characterized the <i>bla</i>_NDM-16-harboring plasmid for the first time. Our study further emphasizes that the co-occurrence of the two prevalent transferrable resistance plasmids in a single isolate is highly significant because infections caused by MCR-1-producing carbapenem-resistant Enterobacteriaceae isolates are increasing each year. It is imperative to perform active surveillance to prevent further dissemination of MCR-1-producing CRE isolates.