International Journal for Numerical Methods in Biomedical Engineering · 2018 · 143 citations · 98 references
EngineeringBiomedical EngineeringPhysicsComputational MechanicsElectrophysiologyFluid DynamicsBiofluid MechanicsCardiac PhysiologyCardiovascular BiomechanicsCardiovascular System ModelingComputational Solid MechanicsElectrophysiological ModelingCardiac Tissue MechanicsCardiac Tissue ModelsComputational Cardiac ModelingFluid - Structure Interaction ModelingFluid-structure Interaction ModelingIncompressible Navier-stokes EquationsLagrangian FormulationMonodomain Models
In this work, we present a fully coupled fluid-electro-mechanical model of a 50th percentile human heart. The model is implemented on Alya, the BSC multi-physics parallel code, capable of running efficiently in supercomputers. Blood in the cardiac cavities is modeled by the incompressible Navier-Stokes equations and an arbitrary Lagrangian-Eulerian (ALE) scheme. Electrophysiology is modeled with a monodomain scheme and the O'Hara-Rudy cell model. Solid mechanics is modeled with a total Lagrangian formulation for discrete strains using the Holzapfel-Ogden cardiac tissue material model. The three problems are simultaneously and bidirectionally coupled through an electromechanical feedback and a fluid-structure interaction scheme. In this paper, we present the scheme in detail and propose it as a computational cardiac workbench.
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Structure of the actin-myosin complex and its implications for muscle contraction
Ivan Rayment, Hazel M. Holden, Michael Whittaker et al. · Science · 1993 · 1.8K citations
Total Excitation of the Isolated Human Heart
D Durrer, R. Th. van Dam, G. E. FREUD et al. · Circulation · 1970 · 1.8K citations · Full text
Medicine, Cardiology, Physiology +14