Organic Letters · 2018 · 54 citations · 75 references
Natural SciencesChemical EngineeringChemistryCatalysisOrganic ChemistryOrganometallic ChemistryCatalyst DesignCatalytic MaterialsCatalytic MechanismsCross-coupling ReactionsOrganometallic ReactivityC - H Bond FunctionalizationC-h ActivationC-h Bond ActivationDirected C - H ActivationReactivityRuthenium-catalyzed CouplingStereoselective C-h FunctionalizationTransition-metal-catalyzed Functionalization
A highly selective and switchable ruthenium-catalyzed ortho C-H alkylation and C-H alkenylation of benzoic acids with allyl alcohols is reported. A complete switch in selectivity is achieved upon tuning the reactivity of the organometallic intermediate in the carboxylate-directed C-H activation to provide access to highly useful motifs such as 2-alkylbenzoic acids and phthalides.
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Efficient catalytic addition of aromatic carbon-hydrogen bonds to olefins
Shinji Murai, Fumitoshi Kakiuchi, Shinya Sekine et al. · Nature · 1993 · 1.4K citations