Concepedia

LEM domain–containing protein 3 antagonizes TGFβ–SMAD2/3 signaling in a stiffness-dependent manner in both the nucleus and cytosol

Dwight M. Chambers, Leandro Moretti, Jennifer J. Zhang, Spencer Cooper, Davis M. Chambers, Philip J. Santangelo, Thomas H. Barker

Journal of Biological Chemistry · 2018 · 32 citations · 69 references

DOIFull text

Open access

Concepts

Abstract

Our work reveals novel LEMD3 biology and stiffness-dependent regulation of TGFβ by LEMD3, providing a novel target to antagonize pathological TGFβ signaling.

References

69

Efficacy and Safety of Nintedanib in Idiopathic Pulmonary Fibrosis

Luca Richeldi, Roland M. du Bois, Ganesh Raghu et al. · New England Journal of Medicine · 2014 · 4.6K citations · Full text

, , +13

A Phase 3 Trial of Pirfenidone in Patients with Idiopathic Pulmonary Fibrosis

Talmadge E. King, Williamson Z. Bradford, Socorro Castro-Bernardini et al. · New England Journal of Medicine · 2014 · 3.9K citations · Full text

, , +13

ClinVar: public archive of interpretations of clinically relevant variants

Melissa Landrum, Jennifer M. Lee, Mark J. Benson et al. · Nucleic Acids Research · 2015 · 2.9K citations · Full text

, , +17

Myofibroblast contraction activates latent TGF-β1 from the extracellular matrix

Pierre‐Jean Wipff, Daniel B. Rifkin, Jean-Jacques Meister et al. · The Journal of Cell Biology · 2007 · 1.3K citations · Full text

, , +15

Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability

Derek C. Radisky, Laurie E. Littlepage, Hong Liu et al. · Nature · 2005 · 1.3K citations · Full text

, , +15