ACS Nano · 2018 · 87 citations · 64 references
PharmacyPharmacokineticsToxicologyNanobiotechnologyNanomaterialsNanotechnologyLung DepositionNanomedicineNanoparticle CharacterizationNanotoxicologyPulmonary ToxicityPulmonary ToxicologyInhaled Nanoparticle KineticsNanoparticle ClearanceNanoparticle Inhalation ToxicityNanoparticle Lung ToxicityNanoparticlesNegative Pressure VentilationPulmonary NanoparticlesRegional Lung Deposition
) In contrast, AuNP-translocation across the air-blood barrier was much smaller leading to persistent retention in secondary organs and tissues in the ranking order liver > soft issue > spleen > kidneys > skeleton > blood > uterus > heart > brain. The age-independent, inhomogeneous AuNP deposition was probably caused by the negative pressure ventilation. Long-term AuNP clearance was dominated by macrophage-mediated transport from the interstitium to the larynx and GIT. Translocation across the rat air-blood barrier appeared to be similar to that of humans for similar sized AuNP.
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