Oxidative stress‐induced dysregulation of excitation–contraction coupling contributes to muscle weakness

Abstract

Our data suggest that the muscle weakness in Sod1^-/- and old WT mice is in part driven by reactive oxygen species-mediated EC uncoupling and supports a role for reduced SERCA pump activity in compromised muscle function. The novel quantitative mechanistic data provided here can lead to potential therapeutic interventions of SERCA dysfunction for sarcopenia and muscle diseases.