American Journal of Research in Medical Sciences · 2018 · 14 citations · 0 references
Veterinary MedicinePharmacologyToxicologyHepatotoxicologyPharmacodynamicsToxicologic PathologyChemical-induced HepatotoxicityHepatic NecrosisHepatic ToxicityHepatotoxicity MechanismsHistopathology Of Toxic InjuryEnzymesHepatoprotective AgentsHepatotoxic MechanismsHerbal Medicine HepatotoxicityNatural Product HepatotoxicityTotal Serum Bilirubin
ABSTRACT: Aim: The present study was designed to evaluate the hepatoprotective effect of ethanolic extract of Allium sativum on thioacetamide (TAA) induced hepatotoxicity in rats. Methods: Male Wistar rats were administered 200 and 400mg/kg/p.o. of ethanolic extract of Allium sativum (EEAS) for 21 days and simultaneously administered TAA 50mg/kg/s.c.1 hr after the respective assigned every 72 hrs. At the end of experimental methods all the animals were sacrificed by cervical decapitation. Blood samples were collected. Serum was separated and analyzed for various parameters like aspartate amino transferase (AST), alanine amino transferase (ALT), alkaline phosphatase (ALP) and total bilirubin using commercially available test kits. Results: Results indicate that EEAS administration blunt TAA induced increase in activities of different marker enzymes of heptocellular injury, viz. AST, ALT, ALP, total bilirubin significantly (p