Platinum drugs, copper transporters and copper chelators

Hypoxia-Induced Lysyl Oxidase Is a Critical Mediator of Bone Marrow Cell Recruitment to Form the Premetastatic Niche

Janine T. Erler, Kevin L. Bennewith, Thomas R. Cox et al. · Cancer Cell · 2009 · 1.2K citations · Full text

Life Sciences, Biochemistry, Cell Biology +17

High resistance to cisplatin in human ovarian cancer cell lines is associated with marked increase of glutathione synthesis.

Andrew K. Godwin, A Meister, P J O'Dwyer et al. · Proceedings of the National Academy of Sciences · 1992 · 928 citations

Medicine, Cancer Biology, Oncology +15

Uptake of the anticancer drug cisplatin mediated by the copper transporter Ctr1 in yeast and mammals

Seiko Ishida, Jaekwon Lee, Dennis J. Thiele et al. · Proceedings of the National Academy of Sciences · 2002 · 915 citations · Full text

Medicine, Molecular Biology, Oncology +13

Copper is required for oncogenic BRAF signalling and tumorigenesis

Donita C. Brady, Matthew S. Crowe, Michelle L. Turski et al. · Nature · 2014 · 599 citations · Full text

Medicine, Molecular Biology, Oncology +12

Abnormal lysosomal trafficking and enhanced exosomal export of cisplatin in drug-resistant human ovarian carcinoma cells

Roohangiz Safaei, Barrett J. Larson, Timothy Cheng et al. · Molecular Cancer Therapeutics · 2005 · 552 citations

Life Sciences, Cell Biology, Oncology +17