A potential key role for alpha-haemolysin of <i>Staphylococcus aureus</i> in mediating chondrocyte death in septic arthritis

Abstract

This study identified Hla as a highly potent <i>S. aureus</i> toxin that caused rapid chondrocyte death in bovine cartilage, with other toxins or metabolic products produced by the bacteria playing a minor role. The identification of Hla in mediating chondrocyte death may assist in the development of therapeutic strategies aimed at reducing the extent of cartilage damage during and after an episode of septic arthritis.<b>Cite this article</b>: I. D. M. Smith, K. M. Milto, C. J. Doherty, S. G. B. Amyes, A. H. R. W. Simpson, A. C. Hall. A potential key role for alpha-haemolysin of <i>Staphylococcus aureus</i> in mediating chondrocyte death in septic arthritis. <i>Bone Joint Res</i> 2018;7:457-467. DOI: 10.1302/2046-3758.77.BJR-2017-0165.R1.