Acute localized exanthematous pustulosis (ALEP) caused by lamotrigine

Abstract

A case of facial acute localized exanthematous pustulosis (ALEP) secondary to lamotrigine is presented. Upon rechallenge with the culprit medication, the patient had acute generalized exanthematous pustulosis (AGEP). This case highlights lamotrigine as a novel causative agent for this type of drug rash, and the unique progression from ALEP to AGEP upon rechallenge.