Tuberculosis and lung diseases · 2018 · 36 citations · 1 references
MedicinePharmacologyPharmacotherapyAntimicrobial PharmacotherapyChemotherapyClinical PharmacologyChemotherapy ResistanceTuberculosis CareTuberculosis PharmacotherapyEfficiency EvaluationMultidrug-resistant Tuberculosis TreatmentPrior Treatment FailureSafety Profile CharacterizationSputum MicroscopySputum Smear ConversionSputum Smear MicroscopyTuberculosis Drug Resistance
The article describes the safety and efficiency evaluation of chemotherapy regimens containing bedaquiline used in 23 tuberculosis patients with multiple and extensive drug resistance in Amur Region. Treatment with bedaquiline (24 weeks) and other anti-tuberculosis drugs was highly effective based on sputum conversion criteria: sputum microscopy – 86.7% (13/15; 95% CI 62.1-96.3%), culture ‒ 82.6%, (19/23; 95% CI 62.7-93.0%), and cavity healing ‒ 73.9% (17/23; 95% CI 53.6-87.5%), of them patients with previous treatment failure made 43.6% (10/23). The best outcomes were achieved in the patients with new tuberculosis and relapses. A satisfactory safety profile was demonstrated during this trial piloting chemotherapy regimens containing bedaquiline, no cardiac toxicity was registered.
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