OncoImmunology · 2018 · 78 citations · 16 references
MedicineImmunologyRadiation OncologyInflammationRadiation BiophysicsRadiobiologyBiological Effects Of RadiationMacrophage BiologyRadiation BiologyRadiation TherapyRadiation ToxicityTissue Responses To RadiationInflammatory Response To RadiationInflammatory Responses To RadiationMacrophage-mediated InjuryMacrophage-mediated Tissue InjuryRadiation Effects On The Immune SystemRadiation FibrosisRadiation-induced FibrosisTherapeutic Target Identification
Radiotherapy can induce toxicity in healthy tissues such as radiation-induced fibrosis (RIF), and macrophages are proposed as new profibrogenic cells. In this Point-of-View, we summarize the role of the immune response in ionizing radiation injury, and we focus on macrophages as a new therapeutic target in RIF.
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Philip Rubin, Jacob N. Finkelstein, Donald L. Shapiro · International Journal of Radiation Oncology*Biology*Physics · 1992 · 214 citations · Full text
Clinical radiation pathology as applied to curative radiotherapy
Philip Rubin, George W. Casarett · Cancer · 1968 · 201 citations