Science Immunology · 2018 · 152 citations · 33 references
Life SciencesImmunologyMicrobiologyImmunoregulationMetabolomicsMicrobial MetabolismGut MicrobiotaHost-microbiome InteractionsMass Spectrometry-based MetabolomicsMicrobial MetabolomicsT Cell BiologyMetabolic Regulation Of T Cell SignalingMetabolomic ChangesMicrobial Metabolite AlterationsMicrobial MetabolitesMicrobial Secondary MetabolitesMicrobiome-associated MetabolitesMicrobiota-derived MetabolitesMicrobiota-driven Immune Regulation
The identification, synthesis, and functional analysis of mycobacterial ligands reveal that MR1T ligands can be distinguished by MR1Ts with diverse TCR usage. These data demonstrate that MR1 can serve as an immune sensor of the microbial ligandome.
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Selection of evolutionarily conserved mucosal-associated invariant T cells by MR1
Emmanuel Treiner, Livine Duban, Seiamak Bahram et al. · Nature · 2003 · 1.1K citations
Life Sciences, Biology, Immunology +12
Human MAIT cells are xenobiotic-resistant, tissue-targeted, CD161hi IL-17–secreting T cells
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