OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information) · 1992 · 29 citations · 0 references
Life SciencesDemographyGeneticsEpidemiologyGenetic EpidemiologyHuman GeneticsCystic FibrosisFibrosisGenetic DisordersGenetic SusceptibilityCarrier FrequenciesCftr Gene MutationsCystic Fibrosis GeneticsFounder Effect AnalysisGenetic Drift EffectsGenetic Drift Modeling
The incidence of cystic fibrosis (CF) in Saguenay-Lac-St.-Jean, a geographically isolated region of Quebec, was estimated to be 1 in 902 during the period 1975-1988. The carrier rate was calculated to be 1 in 15 inhabitants. The high incidence of CF in Saguenay-Lac-St.-Jean is probably the result of a founder effect and genetic drift for one or more mutations. Historical, demographic, and social factors also may have contributed to the high incidence.