Blood Advances · 2018 · 34 citations · 59 references
Life SciencesGeneticsImmunologyImmunogeneticsInflammationMedical GeneticsCytokine Gene PolymorphismHuman Leukocyte Antigen SystemInnate Immune Gene PolymorphismsInterleukin Gene VariantsPatient StratificationTransplantation ImmunogeneticsCytokine Promoter PolymorphismCytokine Receptor PolymorphismsGermline Susceptibility MarkersGraft-versus-host Disease BiomarkersInflammatory Gene PolymorphismsInterleukin-6 Gene PolymorphismsPatient-specific Risk StratificationSingle Nucleotide Polymorphism-based Prediction
Key Points A risk model using donor and recipient cytokine gene polymorphisms and clinical variables significantly improves GVHD risk stratification. The model is useful in identifying patients with low-risk of developing severe GVHD, but results must be confirmed in prospective studies.
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