Levels of Resistance to Pyrethroid among Distinct<i>kdr</i>Alleles in<i>Aedes aegypti</i>Laboratory Lines and Frequency of<i>kdr</i>Alleles in 27 Natural Populations from Rio de Janeiro, Brazil

Abstract

The Na_VR1 and Na_VR2 <i>kdr</i> alleles confer resistance to the pyrethroid deltamethrin in homozygotes and R1R2 heterozygotes, being the R2R2 most resistant genotype. The allele containing duplication in the Na_V gene, with a mutation in the 1011 site, did not confer resistance under the tested conditions. The frequencies of the "resistant genotypes" are elevated in <i>Ae. aegypti</i> natural populations from Rio de Janeiro.