lac repressor mutants with double or triple exchanges in the recognition helix bind specifically to lac operator variants with multiple exchanges.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

Ulrich K. Laemmli · Nature · 1970 · 251.6K citations

Life Sciences, Microbiology, Molecular Biology +14

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

Harry Towbin, T. Staehelin, J. Gordon · Proceedings of the National Academy of Sciences · 1979 · 53.8K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +13

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

Haider Raza, Annie John, Abderrahim Nemmar · Cellular Physiology and Biochemistry · 2013 · 47.3K citations · Full text

Life Sciences, Immunology, Toxicology +17

A new method for sequencing DNA.

Allan M. Maxam, Wendy V. Gilbert · Proceedings of the National Academy of Sciences · 1977 · 8K citations · Full text

Life Sciences, Biology, Molecular Biology +16

Crystal structure of trp represser/operator complex at atomic resolution

Zbyszek Otwinowski, Richard W. Schevitz, R.-G. Zhang et al. · Nature · 1988 · 910 citations

Natural Sciences, Molecular Biology, Physics +14