Nanostructured titanium regulates osseointegration via influencing macrophage polarization in the osteogenic environment

Abstract

It is suggested that the intrinsic immunomodulatory effects of nanomaterials are not only crucial to evaluate the in vivo biocompatibility but also required to determine the final osseointegration. To clarify the immune response and osseointegration may be beneficial for the designation and optimization of the bone implant.