Concepedia

Localization of DNA sequences in region Xp21 of the human X chromosome: search for molecular markers close to the Duchenne muscular dystrophy locus.

de Martinville B, Kunkel Lm, G.A.P. Bruns, François Morlé, Mandel Jl, A.L. Horwich, Latt Sa, Gusella Jf, D Housman

PubMed · 1985 · 85 citations · 35 references

Concepts

Abstract

Panels of somatic cell hybrid lines carrying various structural rearrangements of the human X chromosome short arm were analyzed with 21 X-chromosome-specific cloned DNA fragments. We mapped these molecular markers to five different regions of the short arm of the X chromosome. The results were confirmed by gene-dosage studies of human lymphoblasts with structurally abnormal X chromosomes. The ornithine transcarbamylase gene and four anonymous DNA sequences map within band Xp21, flanking the presumed locus for Duchenne muscular dystrophy.

References

35

Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I

Peter Rigby, Marianne Dieckmann, Carl Rhodes et al. · Journal of Molecular Biology · 1977 · 11.7K citations

, , +14

Selection of Hybrids from Matings of Fibroblasts in vitro and Their Presumed Recombinants

John W. Littlefield · Science · 1964 · 2.1K citations

, , +6

Simple and rapid fluorimetric method for DNA microassay

Jan Kapuściński, B Skoczylas · Analytical Biochemistry · 1977 · 487 citations

, , +6

Minor Xp21 chromosome deletion in a male associated with expression of Duchenne muscular dystrophy, chronic granulomatous disease, retinitis pigmentosa, and McLeod syndrome.

Uta Francke, HD Ochs, de Martinville B et al. · PubMed · 1985 · 455 citations

, , +13

Linkage analysis of two cloned DNA sequences flanking the Duchenne muscular dystrophy locus on the short arm of the human X chromosome

Kay E. Davies, P. Pearson, Peter S. Harper et al. · Nucleic Acids Research · 1983 · 393 citations · Full text

, , +8