Regulation of feeding by somatostatin neurons in the tuberal nucleus

Abstract

The tuberal nucleus (TN) is a surprisingly understudied brain region. We found that somatostatin (SST) neurons in the TN, which is known to exhibit pathological or cytological changes in human neurodegenerative diseases, play a crucial role in regulating feeding in mice. GABAergic tuberal SST (^TNSST) neurons were activated by hunger and by the hunger hormone, ghrelin. Activation of ^TNSST neurons promoted feeding, whereas inhibition reduced it via projections to the paraventricular nucleus and bed nucleus of the stria terminalis. Ablation of ^TNSST neurons reduced body weight gain and food intake. These findings reveal a previously unknown mechanism of feeding regulation that operates through orexigenic ^TNSST neurons, providing a new perspective for understanding appetite changes.