Design, synthesis and pharmacological evaluation of novel 2-chloro-3-(1<i>H</i>-benzo[<i>d</i>]imidazol-2-yl)quinoline derivatives as antitumor agents: <i>in vitro</i> and <i>in vivo</i> antitumor activity, cell cycle arrest and apoptotic response

Wenbin Kuang, Ri-Zhen Huang, Yilin Fang, Gui-Bin Liang, Chenhui Yang, Xian‐Li Ma, Ye Zhang

RSC Advances · 2018 · 16 citations · 22 references

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Abstract

A series of novel 2-chloro-3-(1<italic>H</italic>-benzo[<italic>d</italic>]imidazol-2-yl)quinoline derivatives were designed and synthesized as antitumor agents under the combination principle. The antitumor activity and mechanisms were then evaluated.

References

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