Halilectin-3, a Lectin from the Marine Sponge Haliclona caerulea, Induces Apoptosis and Autophagy in Human Breast Cancer MCF7 Cells Through Caspase-9 Pathway and LC3-II Protein Expression - Concepedia

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Halilectin-3, a Lectin from the Marine Sponge Haliclona caerulea, Induces Apoptosis and Autophagy in Human Breast Cancer MCF7 Cells Through Caspase-9 Pathway and LC3-II Protein Expression

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2018

Year

Luiz Gonzaga do Nascimento Neto, M. Guadalupe Cabral, Rômulo Farias Carneiro, Zélia Silva, Francisco Vassiliepe Sousa Arruda, Celso Shiniti Nagano, Alexandra R. Fernandes, Alexandre Holanda Sampaio, Edson Holanda Teixeira, Paula A. Videira

Anti-Cancer Agents in Medicinal Chemistry

Abstract

The apoptotic effect of H3 may be related to a balance between apoptotic and autophagic cell death, mediated by increased expression of CASP 9 and LC3-II. To the best of our knowledge this is the first report about a sponge lectin triggering both apoptosis and autophagy in MCF7 cell.