Regioselective Radical Ring Closure of Tertiary Enamides to the Synthesis of Trifluoroethyl‐containing <i>N</i>‐Acyl Isoindoline and <i>N</i>‐Acyl Tetrahydroisoquinoline Derivatives

Abstract

Abstract The regioselectivity of radical addition and cyclization reaction of tertiary enamides between 5‐membered benzoyl group and 5/6/7‐membered benzyl group ring closure was investigated, and trifluoroethyl ‐containing N ‐Acyl isoindolines, N ‐acyl tetrahydro‐isoquinolines, and N ‐benzoyl tetrahydro‐1 H ‐benzo[c]azepine were obtained in moderate to good yields with high atom economy. Possible reaction pathway for the formation of the products was also discussed in this paper. magnified image